Protein interaction networks computational analysis the analysis of protein protein interactions is fundamental to the understanding of cellular organization processes and functions pro teins seldom act as single isolated species rather proteins involved in the same cellular processes often interact with each other. To cater to the need analysis of protein interaction networks pins has gained importance as one of the promising strategies the present review aims to discuss various computational approaches to analyse the pins in context to infectious diseases topology and modularity analysis of the network with their biological relevance and the scenario till date about host pathogen and intra pathogenic protein interaction studies were delineated this would provide useful insights to the research . The analysis of protein protein interactions is fundamental to the understanding of cellular organization processes and functions recent large scale investigations of protein protein interactions using such techniques as two hybrid systems mass spectrometry and protein microarrays have enriched the available protein interaction data and facilitated the construction of integrated protein . This book provides a comprehensive understanding of the computational methods available for the analysis of protein protein interaction networks it offers an in depth survey of a range of